Lin28 mediates radiation resistance of breast cancer cells via regulation of caspase, H2A.X and Let-7 signaling.

Resistance to radiation therapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to breast tumorigenesis; however, the relationship between Lin28 and radioresistance remains unknown. In this study, we investigated the association of Lin28 with radiation...

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Bibliographic Details
Main Authors: Linbo Wang, Chao Yuan, Kezhen Lv, Shuduo Xie, Peifen Fu, Xiaojiao Liu, Yongxia Chen, Chuan Qin, Wuguo Deng, Wenxian Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3688678?pdf=render