The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology

The Interplay of Apoes with Syndecans in Influencing Key Cellular Events of Amyloid Pathology

Apolipoprotein E (ApoE) isoforms exert intricate effects on cellular physiology beyond lipid transport and metabolism. ApoEs influence the onset of Alzheimer’s disease (AD) in an isoform-dependent manner: ApoE4 increases AD risk, while ApoE2 decreases it. Previously we demonstrated that syndecans, a...

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Bibliographic Details
Main Authors: Anett Hudák, Katalin Jósvay, Ildikó Domonkos, Annamária Letoha, László Szilák, Tamás Letoha
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
ApoE
amyloid beta
syndecans
protein aggregation
endocytosis
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/22/13/7070

Internet

https://www.mdpi.com/1422-0067/22/13/7070

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