A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.

A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.

Autoimmune gastritis results from the breakdown of T cell tolerance to the gastric H(+)/K(+) ATPase. The gastric H(+)/K(+) ATPase is responsible for the acidification of gastric juice and consists of an α subunit (H/Kα) and a β subunit (H/Kβ). Here we show that CD4(+) T cells from H/Kα-deficient mic...

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Bibliographic Details
Main Authors: Eric Tu, Desmond K Y Ang, Thea V Hogan, Simon Read, Cheryl P Z Chia, Paul A Gleeson, Ian R van Driel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22096532/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22096532/?tool=EBI

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