Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment are unclear. Here, the authors use RNA-sequencing and Drosophila screening to identify Rab11b-mediated endosomal recycling as a unique mechanism for adaptation to a challenging metastatic microenvironment, whic...

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Bibliographic Details
Main Authors: Erin N. Howe, Miranda D. Burnette, Melanie E. Justice, Patricia M. Schnepp, Victoria Hedrick, James W. Clancy, Ian H. Guldner, Alicia T. Lamere, Jun Li, Uma K. Aryal, Crislyn D’Souza-Schorey, Jeremiah J. Zartman, Siyuan Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16832-2

Internet

https://doi.org/10.1038/s41467-020-16832-2

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