Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin

Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin

Carcinoma of unknown primary (CUP) is a type of metastatic cancer, the primary tumor site of which cannot be identified. CUP occupies approximately 5% of cancer incidences in the United States with usually unfavorable prognosis, making it a big threat to public health. Traditional methods to identif...

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Bibliographic Details
Main Authors: Haiyan Liu, Chun Qiu, Bo Wang, Pingping Bing, Geng Tian, Xueliang Zhang, Jun Ma, Bingsheng He, Jialiang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor tissue-of-origin
DNA methylation
gene expression
somatic mutation
multi-classifier XGBoost
pearson correlation algorithm
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.619330/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.619330/full

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