Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice

Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice

Alveolar macrophages (AMs) are differentially regulated by human surfactant protein-A1 (SP-A1) or SP-A2. However, AMs are very heterogeneous and differences are difficult to characterize in intact cells. Using the Toponome Imaging System (TIS), an imaging technique that uses sequential immunostainin...

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Bibliographic Details
Main Authors: David S. Phelps, Vernon M. Chinchilli, Judith Weisz, Lili Yang, Debra Shearer, Xuesheng Zhang, Joanna Floros
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-12-01
Series:JCI Insight
Subjects:
Immunology
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.141410

Internet

https://doi.org/10.1172/jci.insight.141410

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