Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose...

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Bibliographic Details
Main Authors: Karolina Frączek, Mattia Ferraiolo, Emmanuel Hermans, Magdalena Bujalska-Zadrozny, Kaja Kasarello, Anna Erdei, Kamila Kulik, Agnieszka Kowalczyk, Piotr Wojciechowski, Dorota Sulejczak, Piotr Sosnowski, Sebastian Granica, Sandor Benyhe, Katarzyna Kaczynska, Lukasz Nagraba, Artur Stolarczyk, Agnieszka Cudnoch-Jedrzejewska, Patrycja Kleczkowska
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Analgesia
Receptor binding
Hybrid compound
Tolerance
Side effects
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520305578

Internet

http://www.sciencedirect.com/science/article/pii/S2211383520305578

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