AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure.

AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure.

Histidine-rich calcium binding protein (HRC) is located in the lumen of sarcoplasmic reticulum (SR) that binds to both triadin (TRN) and SERCA affecting Ca(2+) cycling in the SR. Chronic overexpression of HRC that may disrupt intracellular Ca(2+) homeostasis is implicated in pathogenesis of cardiac...

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Bibliographic Details
Main Authors: Chang Sik Park, Hyeseon Cha, Eun Jeong Kwon, Dongtak Jeong, Roger J Hajjar, Evangelia G Kranias, Chunghee Cho, Woo Jin Park, Do Han Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3429470?pdf=render

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http://europepmc.org/articles/PMC3429470?pdf=render

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