Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation

Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation

Abstract Background Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irradiation. Methods Gene expression analysis was perf...

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Bibliographic Details
Main Authors: Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris, Victor L. Thijssen
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Radiotherapy
Type I interferons
Immune response
Online Access:https://doi.org/10.1186/s13046-021-01962-2

Internet

https://doi.org/10.1186/s13046-021-01962-2

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