In Vitro Cytotoxicity and In Vivo Antitumor Efficacy of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with a Bulky Substituent at Tetrazole C5

In Vitro Cytotoxicity and In Vivo Antitumor Efficacy of Tetrazolato-Bridged Dinuclear Platinum(II) Complexes with a Bulky Substituent at Tetrazole C5

Tetrazolato-bridged dinuclear platinum(II) complexes ([{cis-Pt(NH3)2}2(μ-OH)(μ-5-R-tetrazolato-N2,N3)]2+; tetrazolato-bridged complexes) are a promising source of next-generation platinum-based drugs. β-Cyclodextrin (β-CD) forms inclusion complexes with bulky organic...

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Bibliographic Details
Main Authors: Seiji Komeda, Masako Uemura, Hiroki Yoneyama, Shinya Harusawa, Keiichi Hiramoto
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Inorganics
Subjects:
anticancer drug
cancer
cyclodextrin
drug discovery
platinum
Online Access:http://www.mdpi.com/2304-6740/7/1/5

Internet

http://www.mdpi.com/2304-6740/7/1/5

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