Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model

Therapeutic approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD-related synaptic and memory dysfunctions when treatment started...

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Bibliographic Details
Main Authors: Georgia-Ioanna Kartalou, Ana Rita Salgueiro-Pereira, Thomas Endres, Angelina Lesnikova, Plinio Casarotto, Paula Pousinha, Kevin Delanoe, Elke Edelmann, Eero Castrén, Kurt Gottmann, Hélène Marie, Volkmar Lessmann
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
fingolimod
FTY720
APP/PS1
spines
long-term potentiation
Online Access:https://www.mdpi.com/1422-0067/21/23/8957

Internet

https://www.mdpi.com/1422-0067/21/23/8957

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