Directly and Indirectly Targeting the Glycine Modulatory Site to Modulate NMDA Receptor Function to Address Unmet Medical Needs of Patients With Schizophrenia

Schizophrenia is a severe mental illness that affects ~1% of the world's population. It is clinically characterized by positive, negative, and cognitive symptoms. Currently available antipsychotic medications are relatively ineffective in improving negative and cognitive deficits, which are rel...

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Bibliographic Details
Main Authors: Ju-Chun Pei, Da-Zhong Luo, Shiang-Shin Gau, Chia-Yuan Chang, Wen-Sung Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.742058/full