Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance. We previously identified a subset of doxorubi...

Full description

Bibliographic Details
Main Authors: Jhuma Saha, Jong Hyuk Kim, Clarissa N. Amaya, Caleb Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Erin B. Dickerson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
angiosarcoma
hemangiosarcoma
propranolol
doxorubicin
drug resistance
lysosome
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.614288/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.614288/full

Similar Items