Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

Abstract Background Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim of this study was to investigate the effect of exosomes derived from mesenchymal stem cells (MSCs) on beta cells under hypoxic conditions and the potential underlying mechanisms. Methods Ex...

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Bibliographic Details
Main Authors: Jin Chen, Junqiu Chen, Yuanhang Cheng, Yunfeng Fu, Hongzhou Zhao, Minying Tang, Hu Zhao, Na Lin, Xiaohua Shi, Yan Lei, Shuiliang Wang, Lianghu Huang, Weizhen Wu, Jianming Tan
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Exosomes
Hypoxia
Beta cells
ER stress
Online Access:http://link.springer.com/article/10.1186/s13287-020-01610-0

Internet

http://link.springer.com/article/10.1186/s13287-020-01610-0

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