Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.

Bibliographic Details
Main Authors:	Christophe Chopard, Phuoc Bao Viet Tong, Petra Tóth, Malvina Schatz, Hocine Yezid, Solène Debaisieux, Clément Mettling, Antoine Gross, Martine Pugnière, Annie Tu, Jean-Marc Strub, Jean-Michel Mesnard, Nicolas Vitale, Bruno Beaumelle
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04674-y

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spelling	doaj-0b76da00f3d140a9bf12b239560dc94a2021-05-11T10:02:40ZengNature Publishing GroupNature Communications2041-17232018-06-019111510.1038/s41467-018-04674-yCyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cellsChristophe Chopard0Phuoc Bao Viet Tong1Petra Tóth2Malvina Schatz3Hocine Yezid4Solène Debaisieux5Clément Mettling6Antoine Gross7Martine Pugnière8Annie Tu9Jean-Marc Strub10Jean-Michel Mesnard11Nicolas Vitale12Bruno Beaumelle13IRIM, UMR 9004, Université de Montpellier-CNRSIRIM, UMR 9004, Université de Montpellier-CNRSINCI, UPR 3212 CNRS, 5 rue Blaise PascalIRIM, UMR 9004, Université de Montpellier-CNRSIRIM, UMR 9004, Université de Montpellier-CNRSIRIM, UMR 9004, Université de Montpellier-CNRSIGH, UPR 1142 CNRS, 141 Rue de la CardonilleIRIM, UMR 9004, Université de Montpellier-CNRSIRCM, INSERM U 1194, 208 Rue des ApothicairesINCI, UPR 3212 CNRS, 5 rue Blaise PascalCNRS, IPHC UMR 7178, Université de StrasbourgIRIM, UMR 9004, Université de Montpellier-CNRSINCI, UPR 3212 CNRS, 5 rue Blaise PascalIRIM, UMR 9004, Université de Montpellier-CNRSIt is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.https://doi.org/10.1038/s41467-018-04674-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle
spellingShingle	Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells Nature Communications
author_facet	Christophe Chopard Phuoc Bao Viet Tong Petra Tóth Malvina Schatz Hocine Yezid Solène Debaisieux Clément Mettling Antoine Gross Martine Pugnière Annie Tu Jean-Marc Strub Jean-Michel Mesnard Nicolas Vitale Bruno Beaumelle
author_sort	Christophe Chopard
title	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_short	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_full	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_fullStr	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_full_unstemmed	Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
title_sort	cyclophilin a enables specific hiv-1 tat palmitoylation and accumulation in uninfected cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-06-01
description	It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane.
url	https://doi.org/10.1038/s41467-018-04674-y
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Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells

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