Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

Abstract Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na+/H+ exchanger-1 (NHE1) in reactive astrocytes causes astrocytic h...

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Bibliographic Details
Main Authors: Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He, Dandan Sun
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Neuroinflammation
Subjects:
Hypoperfusion
Demyelination
Gliosis
Na+/H+ exchanger
Vascular dementia
Online Access:https://doi.org/10.1186/s12974-021-02234-8

Internet

https://doi.org/10.1186/s12974-021-02234-8

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