The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

Glucose induces insulin release from pancreatic β-cells by stimulating ATP synthesis, membrane depolarisation and Ca(2+) influx. As well as activating ATP-consuming processes, cytosolic Ca(2+) increases may also potentiate mitochondrial ATP synthesis. Until recently, the ability to study the role of...

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Bibliographic Details
Main Authors: Andrei I Tarasov, Francesca Semplici, Magalie A Ravier, Elisa A Bellomo, Timothy J Pullen, Patrick Gilon, Israel Sekler, Rosario Rizzuto, Guy A Rutter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3400633?pdf=render

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http://europepmc.org/articles/PMC3400633?pdf=render

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