The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.
Glucose induces insulin release from pancreatic β-cells by stimulating ATP synthesis, membrane depolarisation and Ca(2+) influx. As well as activating ATP-consuming processes, cytosolic Ca(2+) increases may also potentiate mitochondrial ATP synthesis. Until recently, the ability to study the role of...
Main Authors: | Andrei I Tarasov, Francesca Semplici, Magalie A Ravier, Elisa A Bellomo, Timothy J Pullen, Patrick Gilon, Israel Sekler, Rosario Rizzuto, Guy A Rutter |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3400633?pdf=render |
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