A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity

A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity

Tumor-targeted chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR-T cells) have demonstrated striking clinical success, but their use has been associated with a constellation of toxicities. A better understanding of the pathogenesis of these toxicities is required to improve the safety pr...

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Bibliographic Details
Main Authors: Joanne A. Hammill, Jacek M. Kwiecien, Anna Dvorkin-Gheva, Vivian W.C. Lau, Christopher Baker, Ying Wu, Ksenia Bezverbnaya, Craig Aarts, Christopher W. Heslen, Galina F. Denisova, Heather Derocher, Katy Milne, Brad H. Nelson, Jonathan L. Bramson
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
cell therapy
chimeric antigen receptor
CAR-T cell
xenograft model
off-tumor toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300516

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http://www.sciencedirect.com/science/article/pii/S2372770520300516

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