Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing

Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing

Abstract Background Deep sequencing of targeted genomic regions is becoming a common tool for understanding the dynamics and complexity of Plasmodium infections, but its lower limit of detection is currently unknown. Here, a new amplicon analysis tool, the Parallel Amplicon Sequencing Error Correcti...

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Bibliographic Details
Main Authors: Angela M. Early, Rachel F. Daniels, Timothy M. Farrell, Jonna Grimsby, Sarah K. Volkman, Dyann F. Wirth, Bronwyn L. MacInnis, Daniel E. Neafsey
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Malaria Journal
Subjects:
Targeted amplicon deep sequencing
Haplotype calling
Multiplicity of infection
Multiclonal infection
Within-host diversity
Molecular epidemiology
Online Access:http://link.springer.com/article/10.1186/s12936-019-2856-1

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http://link.springer.com/article/10.1186/s12936-019-2856-1

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