Unrestrained Gαi2 Signaling Disrupts Neutrophil Trafficking, Aging, and Clearance

Unrestrained Gαi2 Signaling Disrupts Neutrophil Trafficking, Aging, and Clearance

Neutrophil trafficking, homeostatic and pathogen elicited, depends upon chemoattractant receptors triggering heterotrimeric G-protein Gαiβγ signaling, whose magnitude and kinetics are governed by RGS protein/Gαi interactions. RGS proteins typically limit Gαi signaling by reducing the duration that G...

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Bibliographic Details
Main Authors: Serena Li-Sue Yan, Il-Young Hwang, Olena Kamenyeva, Juraj Kabat, Ji Sung Kim, Chung Park, John H. Kehrl
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
neutrophil
chemotaxis
trafficking
chemoattractants
G-protein
intravital
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.679856/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.679856/full

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