The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Abstract The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression of the p75NTR pan-neurotrophin receptor. Even though p75NTR targeti...

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Bibliographic Details
Main Authors: Viviana Pérez, Francisca Bermedo-Garcia, Diego Zelada, Felipe A. Court, Miguel Ángel Pérez, Marco Fuenzalida, Johanna Ábrigo, Claudio Cabello-Verrugio, Guillermo Moya-Alvarado, Juan Carlos Tapia, Vicente Valenzuela, Claudio Hetz, Francisca C. Bronfman, Juan Pablo Henríquez
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Acta Neuropathologica Communications
Subjects:
Neuromuscular junction
p75NTR
Neurotrophin
Motor neuron
Synaptic vesicles
Online Access:http://link.springer.com/article/10.1186/s40478-019-0802-7

Internet

http://link.springer.com/article/10.1186/s40478-019-0802-7

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