Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.

Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.

BACKGROUND:Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution. The surface of Leishmania parasites is covered in a dense glycocalyx consisting of primarily lipophosphoglycan...

Full description

Bibliographic Details
Main Authors: Michelle A Favila, Nicholas S Geraci, Asha Jayakumar, Suzanne Hickerson, Janet Mostrom, Salvatore J Turco, Stephen M Beverley, Mary Ann McDowell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4667916?pdf=render

Internet

http://europepmc.org/articles/PMC4667916?pdf=render

Similar Items