Profiling of Ubiquitination Pathway Genes in Peripheral Cells from Patients with Frontotemporal Dementia due to C9ORF72 and GRN Mutations

Profiling of Ubiquitination Pathway Genes in Peripheral Cells from Patients with Frontotemporal Dementia due to C9ORF72 and GRN Mutations

We analysed the expression levels of 84 key genes involved in the regulated degradation of cellular protein by the ubiquitin-proteasome system in peripheral cells from patients with frontotemporal dementia (FTD) due to C9ORF72 and GRN mutations, as compared with sporadic FTD and age-matched controls...

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Bibliographic Details
Main Authors: Maria Serpente, Chiara Fenoglio, Sara M. G. Cioffi, Rossana Bonsi, Andrea Arighi, Giorgio G. Fumagalli, Laura Ghezzi, Elio Scarpini, Daniela Galimberti
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:International Journal of Molecular Sciences
Subjects:
frontotemporal lobar degeneration
progranulin
C9ORF72
ubiquitination
E2 ubiquitin conjugating enzyme
Online Access:http://www.mdpi.com/1422-0067/16/1/1385

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http://www.mdpi.com/1422-0067/16/1/1385

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