B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes

B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes

Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and the 116C-NOD mice. In NOD-PerIg mice, B-lymphocytes acquire an activated proli...

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Bibliographic Details
Main Authors: Leire Egia-Mendikute, Berta Arpa, Estela Rosell-Mases, Marta Corral-Pujol, Jorge Carrascal, Jorge Carrillo, Conchi Mora, Harold Chapman, Anaïs Panosa, Marta Vives-Pi, Thomas Stratmann, David Serreze, Joan Verdaguer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
NOD mouse
transgenic mouse model
B-lymphocyte phernotype
T-lymphocyte phernotype
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01732/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01732/full

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