Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Abstract Background The receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) is a poor prognostic factor; however, the prognostic significance of missense mutation in the tyrosine kinase domain (FLT3-TKD) is controversial. Furthermore, the accomp...

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Bibliographic Details
Main Authors: Wei Guan, Lei Zhou, Yan Li, Erna Yang, Yangyang Liu, Na Lv, Lin Fu, Yi Ding, Nan Wang, Nan Fang, Qian Liu, Binan Wang, Fuwei Li, Juan Zhang, Maoquan Wang, Lili Wang, Yu Jing, Yonghui Li, Li Yu
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Experimental Hematology & Oncology
Subjects:
Acute myeloid leukemia
FLT3-ITD
FLT3-TKD
TET2
Next-generation sequencing
Online Access:https://doi.org/10.1186/s40164-021-00207-4

Internet

https://doi.org/10.1186/s40164-021-00207-4

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