Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys

Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys

MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 mg/kg every other day for a total of 21 infusions, and effects on lipids, (apo)lipoproteins, and ex-vivo cholesterol efflux ca...

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Bibliographic Details
Main Authors: Herman J. Kempen, Monica Gomaraschi, S. Eralp Bellibas, Stephanie Plassmann, Brad Zerler, Heidi L. Collins, Steven J. Adelman, Laura Calabresi, Peter L.J. Wijngaard
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Journal of Lipid Research
Subjects:
palmitoyl-oleoyl-phosphatidylcholine
ABCA1-mediated cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351257

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http://www.sciencedirect.com/science/article/pii/S0022227520351257

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