Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys
MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 mg/kg every other day for a total of 21 infusions, and effects on lipids, (apo)lipoproteins, and ex-vivo cholesterol efflux ca...
Main Authors: | Herman J. Kempen, Monica Gomaraschi, S. Eralp Bellibas, Stephanie Plassmann, Brad Zerler, Heidi L. Collins, Steven J. Adelman, Laura Calabresi, Peter L.J. Wijngaard |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2013-09-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520351257 |
Similar Items
-
Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size
by: Herman J. Kempen, et al.
Published: (2014-01-01) -
ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I
by: Lee, Jee Yeon
Published: (2012) -
ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I
by: Lee, Jee Yeon
Published: (2012) -
ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I
by: Lee, Jee Yeon
Published: (2012) -
ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I
by: Lee, Jee Yeon
Published: (2012)