Human platelet lysate in mesenchymal stromal cell expansion according to a GMP grade protocol: a cell factory experience

Human platelet lysate in mesenchymal stromal cell expansion according to a GMP grade protocol: a cell factory experience

Abstract Background The use of platelet lysate (PL) for the ex-vivo expansion of mesenchymal stromal/stem cells (MSCs) was initially proposed by Doucet et al. in 2005, as an alternative to animal serum. Moreover, regulatory authorities discourage the use of fetal bovine serum (FBS) or other animal d...

Full description

Bibliographic Details
Main Authors: Valentina Becherucci, Luisa Piccini, Serena Casamassima, Silvia Bisin, Valentina Gori, Francesca Gentile, Riccardo Ceccantini, Elena De Rienzo, Barbara Bindi, Paola Pavan, Vanessa Cunial, Elisa Allegro, Stefano Ermini, Francesca Brugnolo, Giuseppe Astori, Franco Bambi
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Stem Cell Research & Therapy
Subjects:
Cell factory
Good manufacturing practice
Mesenchymal stromal/stem cells
Platelet lysate
Fetal bovine serum
Advanced therapy medicinal products
Online Access:http://link.springer.com/article/10.1186/s13287-018-0863-8

Internet

http://link.springer.com/article/10.1186/s13287-018-0863-8

Similar Items