Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem<sup>®</sup>-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke

Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem<sup>®</sup>-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke

Ischemic stroke is a leading cause of death and disability worldwide. Potential therapeutics aimed at neural repair and functional recovery are limited in their blood-brain barrier permeability and may exert systemic or off-target effects. We examined the effects of brain-derived neurotrophic factor...

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Bibliographic Details
Main Authors: Kristine Ravina, Denise I. Briggs, Sezen Kislal, Zuha Warraich, Tiffany Nguyen, Rachel K. Lam, Thomas I. Zarembinski, Mehrdad Shamloo
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
brain-derived neurotrophic factor
functional recovery
hydrogel
ischemic stroke
neuroinflammation
Online Access:https://www.mdpi.com/1422-0067/19/12/3782

Internet

https://www.mdpi.com/1422-0067/19/12/3782

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