The Bradykinin-BDKRB1 Axis Regulates <i>Aquaporin 4</i> Gene Expression and Consequential Migration and Invasion of Malignant Glioblastoma Cells via a Ca<sup>2+</sup>-MEK1-ERK1/2-NF-κB Mechanism

The Bradykinin-BDKRB1 Axis Regulates <i>Aquaporin 4</i> Gene Expression and Consequential Migration and Invasion of Malignant Glioblastoma Cells via a Ca<sup>2+</sup>-MEK1-ERK1/2-NF-κB Mechanism

Glioblastoma multiforme (GBM) is the most common form of brain tumor and is very aggressive. Rapid migration and invasion of glioblastoma cells are two typical features driving malignance of GBM. Bradykinin functionally prompts calcium influx via activation of bradykinin receptor B1/B2 (BDKRB1/2). I...

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Bibliographic Details
Main Authors: Ding-Ping Sun, Yuan-Wen Lee, Jui-Tai Chen, Yung-Wei Lin, Ruei-Ming Chen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
glioblastoma
bradykinin-bdkrb1 axis
calcium influx
mek1-erk1/2-nf-κb
aquaporin 4
cell migration/invasion
Online Access:https://www.mdpi.com/2072-6694/12/3/667

Internet

https://www.mdpi.com/2072-6694/12/3/667

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