Subcellular drug targeting illuminates local kinase action

Subcellular drug targeting illuminates local kinase action

Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. We exploited the AKAP targeting concept to create g...

Full description

Bibliographic Details
Main Authors: Paula J Bucko, Chloe K Lombard, Lindsay Rathbun, Irvin Garcia, Akansha Bhat, Linda Wordeman, F Donelson Smith, Dustin J Maly, Heidi Hehnly, John D Scott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
kinases
local signaling
mitosis
Online Access:https://elifesciences.org/articles/52220

Internet

https://elifesciences.org/articles/52220

Similar Items