Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Brain-derived neurotrophic factor (BDNF) controls the survival, growth, and function of neurons both during the development and in the adult nervous system. Bdnf is transcribed from several distinct promoters generating transcripts with alternative 5' exons. Bdnf transcripts initiated at the fi...

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Bibliographic Details
Main Authors: Jürgen Tuvikene, Eli-Eelika Esvald, Annika Rähni, Kaie Uustalu, Anna Zhuravskaya, Annela Avarlaid, Eugene V Makeyev, Tõnis Timmusk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
enhancer
BDNF
neurons
CRISPR
TCF4
E-box
Online Access:https://elifesciences.org/articles/65161

Internet

https://elifesciences.org/articles/65161

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