Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation

Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation

Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration of intravenous Coagulation Factor Xa (FXa), on the growth of solid human tumors...

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Bibliographic Details
Main Authors: Maximiliano Arce, Mauricio P. Pinto, Macarena Galleguillos, Catalina Muñoz, Soledad Lange, Carolina Ramirez, Rafaela Erices, Pamela Gonzalez, Ethel Velasquez, Fabián Tempio, Mercedes N. Lopez, Flavio Salazar-Onfray, Kelly Cautivo, Alexis M. Kalergis, Sebastián Cruz, Álvaro Lladser, Lorena Lobos-González, Guillermo Valenzuela, Nixa Olivares, Claudia Sáez, Tania Koning, Fabiola A. Sánchez, Patricia Fuenzalida, Alejandro Godoy, Pamela Contreras Orellana, Lisette Leyton, Roberta Lugano, Anna Dimberg, Andrew F.G. Quest, Gareth I. Owen
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
cancer
metastasis
melanoma
blood coagulation
vascular endothelium
inflammation
Online Access:https://www.mdpi.com/2072-6694/11/8/1103

Internet

https://www.mdpi.com/2072-6694/11/8/1103

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