Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human Anti-C. trachomatis Antibodies

Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human Anti-C. trachomatis Antibodies

For detection of anti-C. trachomatis antibodies by serological assays, use of classical chlamydial antigens results in high cross-reactivity and poor sensitivity. Previously, we discovered 48 strongly reactive peptide antigens of C. trachomatis-specific B-cell epitopes from 21 immunodominant protein...

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Bibliographic Details
Main Authors: K. Shamsur Rahman, Toni Darville, Harold C. Wiesenfeld, Sharon L. Hillier, Bernhard Kaltenboeck
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mSphere
Subjects:
Chlamydia trachomatis
diagnosis
serology
antibody detection
B-cell epitopes
peptide antigens
ELISA
cross-reactivity
species-specific
antibody isotypes
IgG
IgG1
IgG3
IgA
IgA1
IgA2
Online Access:https://doi.org/10.1128/mSphere.00484-18

Internet

https://doi.org/10.1128/mSphere.00484-18

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