Editing of the TRIM5 Gene Decreases the Permissiveness of Human T Lymphocytic Cells to HIV-1

Editing of the TRIM5 Gene Decreases the Permissiveness of Human T Lymphocytic Cells to HIV-1

Tripartite-motif-containing protein 5 isoform α (TRIM5α) is a cytoplasmic antiretroviral effector upregulated by type I interferons (IFN-I). We previously showed that two points mutations, R332G/R335G, in the retroviral capsid-binding region confer human TRIM5α the capacity to target and strongly re...

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Bibliographic Details
Main Authors: Kevin Désaulniers, Levine Ortiz, Caroline Dufour, Alix Claudel, Mélodie B. Plourde, Natacha Merindol, Lionel Berthoux
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
HIV-1
TRIM5α
genome editing
CRISPR
restriction factor
interferon
Online Access:https://www.mdpi.com/1999-4915/13/1/24

Internet

https://www.mdpi.com/1999-4915/13/1/24

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