Advances for the Hepatitis A Virus Antigen Production Using a Virus Strain With Codon Frequency Optimization Adjustments in Specific Locations

Advances for the Hepatitis A Virus Antigen Production Using a Virus Strain With Codon Frequency Optimization Adjustments in Specific Locations

The available cell-adapted hepatitis A virus (HAV) strains show a very slow replication phenotype hampering the affordable production of antigen. A fast-growing strain characterized by the occurrence of mutations in the internal ribosome entry site (IRES), combined with changes in the codon composit...

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Bibliographic Details
Main Authors: Gemma Chavarria-Miró, Montserrat de Castellarnau, Cristina Fuentes, Lucía D’Andrea, Francisco-Javier Pérez-Rodríguez, Nerea Beguiristain, Albert Bosch, Susana Guix, Rosa M. Pintó
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
hepatitis A
HAV
codon composition
IRES
vaccine
FRhK-4
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.642267/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.642267/full

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