Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes.

Angiotensin-(1-12) [Ang-(1-12)] functions as an endogenous substrate for the productions of Ang II and Ang-(1-7) by a non-renin dependent mechanism. This study evaluated whether Ang-(1-12) is incorporated by neonatal cardiac myocytes and the enzymatic pathways of ¹²⁵I-Ang-(1-12) metabolism in the ca...

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Bibliographic Details
Main Authors: Sarfaraz Ahmad, Jasmina Varagic, Brian M Westwood, Mark C Chappell, Carlos M Ferrario
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3018413?pdf=render