N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL

N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL

Human plasma PAF-AH (platelet-activating factor-acetylhydrolase) is a Ca2+-independent phospholipase A2 of hematopoietic origin associated with LDL and HDL; it degrades PAF and oxidizes phospholipids. We show that human macrophages synthesize PAF-AH as a premedial Golgi precursor containing high man...

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Bibliographic Details
Main Authors: Alexandros D. Tselepis, Sonia-Athena P. Karabina, Dominique Stengel, Remi Piédagnel, M. John Chapman, Ewa Ninio
Format: Article
Language:English
Published: Elsevier 2001-10-01
Series:Journal of Lipid Research
Subjects:
atherogenesis
lipoproteins
macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322197

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http://www.sciencedirect.com/science/article/pii/S0022227520322197

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