Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose

Resolvin D1 Modulates the Intracellular VEGF-Related miRNAs of Retinal Photoreceptors Challenged With High Glucose

Stimulation of retinal photoreceptors with elevated glucose concentration (30 mM) for 96 h, served as diabetic retinopathy in vitro model to study Resolvin D1 (50 nM) effects on neovascularization. VEGF and anti-angiogenic miR-20a-3p, miR-20a-5p, miR-106a-5p, and miR-20b expression was assessed eith...

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Bibliographic Details
Main Authors: Rosa Maisto, Maria Consiglia Trotta, Francesco Petrillo, Sara Izzo, Giovanna Cuomo, Roberto Alfano, Anca Hermenean, Jorge Miquel Barcia, Marilena Galdiero, Chiara Bianca Maria Platania, Claudio Bucolo, Michele D’Amico
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
retinal photoreceptors
exosomes
miRNAs
resolvin D1
VEGF
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00235/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00235/full

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