LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production

LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production

Abstract Background Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the presence of pathogenic autoantibodies associated with polyclonal B cell hyperreactivity. Previous study reported that autophagy-related gene Leucine-rich repeat kinase 2 (LRRK2) was likely...

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Bibliographic Details
Main Authors: Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang, Ying Wang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Translational Medicine
Subjects:
System lupus erythematosus
Leucine-rich repeat kinase 2
Lupus-like mouse model
B cell differentiation
Antibody production
Online Access:http://link.springer.com/article/10.1186/s12967-019-1786-6

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http://link.springer.com/article/10.1186/s12967-019-1786-6

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