Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury

Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury

Different profiles of alloantibody responses are observed in the clinic, with those that persist, often despite targeted treatment, associated with poorer long-term transplant outcomes. Although such responses would suggest an underlying germinal center (GC) response, the relationship to cellular ev...

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Bibliographic Details
Main Authors: Manu Chhabra, Jawaher Alsughayyir, M. Saeed Qureshi, Mekhola Mallik, Jason M. Ali, Ivonne Gamper, Ellen L. Moseley, Sarah Peacock, Vasilis Kosmoliaptsis, Martin J. Goddard, Michelle A. Linterman, Reza Motallebzadeh, Gavin J. Pettigrew
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
allograft
humoral allograft rejection
germinal center (GC)
extrafollicular B cell response
transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03038/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03038/full

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