Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin

Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin

The Keggin-type polyoxometalate [γ-SiW10O36]8− was covalently modified to obtain a bis-biotinylated conjugate able to bind avidin. Spectroscopic studies such as UV-vis, fluorimetry, circular dichroism, coupled to surface plasmon resonance technique were used to highlight the unique interplay of supr...

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Bibliographic Details
Main Authors: Valeria A. Zamolo, Gloria Modugno, Elisa Lubian, Alessandro Cazzolaro, Fabrizio Mancin, Livia Giotta, Disma Mastrogiacomo, Ludovico Valli, Alessandra Saccani, Silke Krol, Marcella Bonchio, Mauro Carraro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Chemistry
Subjects:
biotin
avidin
polyoxometalates
recognition
surface plasmon resonance
bio-hybrids
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00278/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00278/full

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