Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.

Recent work has highlighted glutaminase (GLS) as a key player in cancer cell metabolism, providing glutamine-derived carbon and nitrogen to pathways that support proliferation. There is significant interest in targeting GLS for cancer therapy, although the gene is not known to be mutated or amplifie...

Full description

Bibliographic Details
Main Authors: Danielle B Ulanet, Kiley Couto, Abhishek Jha, Sung Choe, Amanda Wang, Hin-Koon Woo, Mya Steadman, Byron DeLaBarre, Stefan Gross, Edward Driggers, Marion Dorsch, Jonathan B Hurov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4264947?pdf=render

Internet

http://europepmc.org/articles/PMC4264947?pdf=render

Similar Items