Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway

Pancreatic cancer is the fourth leading cause of cancer death, with a 5-year survival rate of only 1–4%. Integrin-mediated cell adhesion is critical for the initiation, progression, and metastasis of cancer. In this study we investigated the role of integrin b4 (ITGB4) and its phosphorylation at ty...

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Bibliographic Details
Main Authors: Xiangli Meng, Peng Liu, Yunhao Wu, Xinlu Liu, Yinpeng Huang, Boqiang Yu, Jiahong Han, Haoyi Jin, Xiaodong Tan
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2019-06-01
Series:Bosnian Journal of Basic Medical Sciences
Subjects:
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/4255