Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

The 5-HT3 receptor is a ligand-gated ion channel, which is expressed in the nervous system. Its antagonists are used clinically for treatment of postoperative- and radiotherapy-induced emesis and irritable bowel syndrome. In order to better understand the structure and function of the 5-HT3 receptor...

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Bibliographic Details
Main Authors: Reka A. Otvos, Janaki Krishnamoorthy Iyer, René van Elk, Chris Ulens, Wilfried M. A. Niessen, Govert W. Somsen, R. Manjunatha Kini, August B. Smit, Jeroen Kool
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Toxins
Subjects:
5-HT3 receptor
5HTBP
high-resolution screening
snake venoms
nano-LC-MS
Online Access:http://www.mdpi.com/2072-6651/7/7/2336

Internet

http://www.mdpi.com/2072-6651/7/7/2336

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