Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma

Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma

Abstract Background Tumor targeting small molecular inhibitors are the most popular treatments for many malignant diseases, including cancer. However, the lower clinical response and drug resistance still limit their clinical efficacies. HGFK1, the first kringle domain of hepatocyte growth factor, h...

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Bibliographic Details
Main Authors: Xiaoge Gao, Pin Jiang, Qian Zhang, Qian Liu, Shuangshuang Jiang, Ling Liu, Maomao Guo, Qian Cheng, Junnian Zheng, Hong Yao
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HGFK1
Sorafenib
Renal cell carcinoma
Autophagy
Cancer stem cell
Online Access:http://link.springer.com/article/10.1186/s13046-019-1348-z

Internet

http://link.springer.com/article/10.1186/s13046-019-1348-z

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