Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice

Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice

Objective: Recent evidence suggests the substantial pathogenic role of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in the development of low-grade chronic inflammatory response, known as “metaflammation,” which contributes to obesity and type 2 diabetes. In...

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Bibliographic Details
Main Authors: Debora Collotta, William Hull, Raffaella Mastrocola, Fausto Chiazza, Alessia Sofia Cento, Catherine Murphy, Roberta Verta, Gustavo Ferreira Alves, Giulia Gaudioso, Francesca Fava, Magdi Yaqoob, Manuela Aragno, Kieran Tuohy, Christoph Thiemermann, Massimo Collino
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Metabolism
Subjects:
Metaflammation
Baricitinib
High-fat-high sugar diet
JAK2-STAT2 pathway
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300831

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http://www.sciencedirect.com/science/article/pii/S2212877820300831

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