The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice

The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice

Red blood cell (RBC) transfusions are essential for patients with hematological disorders and bone marrow failure syndromes. Despite ABO matching, RBC transfusions can lead to production of alloantibodies against “minor” blood group antigens. Non-ABO alloimmunization is a leading cause of transfusio...

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Bibliographic Details
Main Authors: David R. Gibb, Samuele Calabro, Dong Liu, Christopher A. Tormey, Steven L. Spitalnik, James C. Zimring, Jeanne E. Hendrickson, Eldad A. Hod, Stephanie C. Eisenbarth
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Subjects:
NLRP3
Inflammasome
Alloimmunization
Conventional dendritic cells (cDCs)
Red blood cell (RBC) storage
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302523

Internet

http://www.sciencedirect.com/science/article/pii/S2352396416302523

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