An extrafollicular pathway for the generation of effector CD8+ T cells driven by the proinflammatory cytokine, IL-12

An extrafollicular pathway for the generation of effector CD8+ T cells driven by the proinflammatory cytokine, IL-12

The proinflammatory cytokine IL-12 drives the generation of terminally differentiated KLRG1+ effector CD8+ T cells. Using a Toxoplasma vaccination model, we delineate the sequence of events that naïve CD8+ T cells undergo to become terminal effectors and the differentiation steps controlled by IL-12...

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Bibliographic Details
Main Authors: Suhagi Shah, Gijsbert M Grotenbreg, Amariliz Rivera, George S Yap
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
Toxoplasma
CD8 T cell
interleukin-12
extrafollicular
effector cell
myeloid DC
Online Access:https://elifesciences.org/articles/09017

Internet

https://elifesciences.org/articles/09017

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